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Signs of an allergic reactionlike rashhivesitchingredswollenblisteredor peeling skin with or without feverwheezingtightness in the chest or throattrouble breathingswallowingor talkingunusual hoarsenessor swelling of the mouthfacelipstongueor throatSigns of bleeding like throwing up blood or throw up that looks like coffee groundscoughing up bloodblood in the urineblackredor tarry stoolsbleeding from the gumsvaginal bleeding that is not normalbruises without a reason or that get biggeror any bleeding that is very bad or that you cannot stopSigns of kidney problems like unable to pass urinechange in how much urine is passedblood in the urineor a big weight gainSigns of high potassium levels like a heartbeat that does not feel normalfeeling confusedfeeling weaklightheadedor dizzyfeeling like passing outnumbness or tinglingor shortness of breathSigns of high blood pressure like very bad headache or dizzinesspassing outor change in eyesightShortness of breatha big weight gainor swelling in the arms or legsChest pain or pressure or a fast heartbeatWeakness on 1 side of the bodytrouble speaking or thinkingchange in balancedrooping on one side of the faceor blurred eyesightFeeling very tired or weakRinging in earsMood changesLow mooddepressionVery bad belly painVery bad back painA very bad skin reactionStevens-Johnson syndrome/toxic epidermal necrolysismay happenIt can cause very bad health problems that may not go awayand sometimes deathGet medical help right away if you have signs like redswollenblisteredor peeling skinwith or without feverred or irritated eyesor sores in your mouththroatnoseor eyes.

NSAIDs cause an increased risk of serious gastrointestinalGIadverse events including bleedingulcerationand perforation of the stomach or intestineswhich can be fatalThese events can occur at any time during use and without warning symptomsElderly patients and patients with a prior history of peptic ulcer disease and/or GI bleeding are at greater risk for serious GI eventssee WARNINGS

Long-term administration of NSAIDs has resulted in renal papillary necrosis and other renal injury.

Kidney problems can sometimes occur with the use of NSAID medicationsincluding mefenamic acidProblems are more likely to occur if you are dehydratedhave heart failure or kidney diseaseare an older adultor if you take certain medicationssee also Drug Interactions sectionDrink plenty of fluids as directed by your doctor to prevent dehydration and tell your doctor right away if you have a change in the amount of urine.

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