Operational aspects of ctxp and ipt are similar and the beneficiary population overlaps; consequently the possibility of co-packaging or co-formulating ctx and isoniazid might be explored to address issues related to logistics, adherence and integration of services.

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Treatment with isoniazid should not be stopped abruptlyeven if you feel betterTo prevent the infection from returning as a result of premature stoppageyou should decrease your dose only as directed by your doctoronly when instructed to do so.

Avoid alcohol while taking isoniazidAlcohol will increase the risk of damage to the liver during treatment with this medication.

For the best effecttake this drug at evenly spaced timesIf you are taking this medication dailytake it at the same time each dayIf you are taking this medication on a weekly scheduletake it on the same day(sof the week and at the same time each dayMark the days on the calendar when you need to take the medication.

If you experience any of the following symptoms or those listed in the IMPORTANT WARNING sectioncall your doctor immediately:

Isoniazid has rarely caused very seriouspossibly fatalliver diseaseThe risk of liver disease is increased in people who are 35 years and olderwho use alcohol or illegal injection drugsor who currently have long-term liver problemsTell your doctor right away if you develop symptoms of liver diseaseincluding persistent nausea/vomitingsevere stomach/abdominal painunusual weakness/tirednessdark urineyellowing eyes/skin.

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everolimus is a cyp3a4 substrate and isoniazid is a moderate cyp3a4 inhibitor.

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